apalutamide will decrease the level or result of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a robust CYP2C19 inducer, with medication which have been CYP2C19 substrates may lead to lower publicity to those medications.

Hyponatremia: Clinically sizeable hyponatremia (sodium three situations the upper limit of standard) to unusual instances with concomitant elevations of overall bilirubin (>two occasions the upper limit of typical) happen to be documented with APTIOM use.

Are allergic to diazepam. Have an eye fixed challenge termed acute slender-angle glaucoma. What should really I notify my health practitioner just before taking VALTOCO?

drospirenone will enhance the level or outcome of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unfamiliar.

Keep away from or Use Alternate Drug. Stay clear of coadministration of delicate CYP3A4 substrates with ivosidenib or change with alternate therapies. If coadministration is unavoidable, keep an eye on people for lack of therapeutic influence of such medicine.

“All over this identical time, nevertheless, I became conscious of VALTOCO. I appreciated that it absolutely was a simple-to-use immediate-use seizure medication. It’s also much less awkward or embarrassing since I don’t should rely upon another person to administer it rectally.

methylprednisolone will lessen the level or outcome of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.

Monitor Carefully (1)belzutifan will lessen the extent or influence of diazepam by influencing hepatic/intestinal check here enzyme CYP3A4 metabolism.

Observe Carefully (1)lenacapavir will increase the stage or result of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism.

Simply because diazepam and its metabolites could possibly be present in human breast milk for extended amounts of time immediately after acute use, individuals really should be encouraged not to breastfeed for an appropriate stretch of time immediately after acquiring treatment method

Continuously keep track of essential symptoms for the duration of sedation and recovery period if coadministered. Very carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.

isoniazid will improve the stage or influence of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.

phenobarbital will decrease the extent or result of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.

Avoid concomitant usage of tucatinib with CYP3A substrates, the place minimum focus improvements may possibly result in serious or everyday living-threatening toxicities. If unavoidable, lessen CYP3A substrate dose In accordance with product labeling.